hmm you could try
Blame!. What i like about this manga is how dark and highly detailed the city is.
Here is a line from the plot summary:
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The Net Terminal Genes appear to be the key to halting the unhindered, chaotic expansion of the Megastructure, as well as a way of stopping the murderous horde known as the Safeguard from destroying all humanity.
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I think it meets the criteria...